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Greater baseline diversity often allows more flexible adaptation

10.1186/s12931-020-01462-5 20

[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Krug SM, Amasheh S, Richter JF, Milatz S, Gunzel D, Westphal JK, Huber O, Schulzke JD, Fromm M

VPS35 in dopamine neurons is required for endosome-to-golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for alpha-synuclein degradation and prevention of pathogenesis of Parkinson's disease

33 (2017): 78647877, 10.1523/JNEUROSCI.0982-17.2017

The amount of dual FAK-paxillin containing focal adhesions was also significantly reduced after treatment with 2012 in a dose-dependent manner with an IC 50 value of 1.26 M (Fig