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153 As a compensatory mechanism, IAPP may activate HIF-1/6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) to protect against oligomer toxicity, thus delaying the loss of cells but at the cost of impairing cell function

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doi: 10.3389/fphar.2025.1576091 Received 13 February 2025 Accepted 14 May 2025 Published 23 May 2025 Volume 16 - 2025 Edited by Prasanth Puthanveetil, Midwestern University, United States Reviewed by Carlos Alan Dias-Junior, So Paulo State University, Brazil Tlio de Almeida Hermes, Federal University of Alfenas, Brazil Updates Copyright 2025 Peng, Deng, Wang, Liang, Wu, Li, Lv, Wu, Zhong, Yao and Jin

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doi: 10.1016/j.jtemb.2023.127331