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Clin Cancer Res 11 : 18841889 Jodrell DI, Bowman A, Rye R, Byrne B, Boddy A, Rafi I, Taylor GA, Johnston A, Clendeninn NJ (1999) A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq (nolatrexed dihydrochloride) given by 10-day oral administration

(2015), small structural changes in a yet to be identified EAAT2 variant could permit such a molecule to become permeable to chloride and act in an inhibitory manner, inducing presynaptic feedback inhibition

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Similar content being viewed by others Main DNA methylation is an epigenetic mark widely studied for its association with diseases such as cancer 1 and autoimmune disorders 2 , with environmental exposures 3 and with other biological phenomena 4,5