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These networks play a crucial role in the reprogramming of glutamine metabolism, which in turn affects various hallmarks of cancer, including cancer cell proliferation, ROS-mediated inhibition of apoptosis, and EMT-associated invasive metastasis

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This microbial LPS can directly translocate to the brain, where it activates microglia through the TLR4/NF-B pathway, promoting type I interferon signaling while suppressing type II interferon-driven autoimmune responses, thereby influencing susceptibility to autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE) [1, 287]

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