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Description
After formation of the trichloroethylene-oxide-CYP, chloral hydrate is the metabolite produced

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Valproic acid can inhibit specific CYP450 isozymes, epoxide hydrolase, and UGT isozymes

In addition, we observed a recurrent mutation in PSPH that leads to an amino acid change from valine to isoleucine (V116I)

DOI: 10.1093/jn/nxab309

Scaini et al., 2022)
