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Manuscript source: Invited manuscript Peer-review started: December 5, 2017 First decision: December 11, 2017 Article in press: February 7, 2018 Specialty type: Gastroenterology and hepatology Country of origin: France Peer-review report classification Grade A (Excellent): A Grade B (Very good): B Grade C (Good): C Grade D (Fair): 0 Grade E (Poor): 0 P- Reviewer: Chetty R, He ST, Savopoulos CG S- Editor: Wang JL L- Editor: A E- Editor: Li RF Contributor Information Vladimir Alexei Morozov, Center for HIV and Retrovirology, Department of Infectious Diseases, Robert Koch Institute, Berlin 13353, Germany

We speculate that mechanisms other than excretion of surplus nitrogen via alternative pathways may be responsible for the relatively rapid decrease in ammonia concentration after intravenous bolus treatment with SB and SPA

CD81-LEL was expressed and purified in SURE cells at the Protein Production Unit, Monash University, Melbourne, as described previously 64,65

Most side effects are reversible upon discontinuation of therapy, but serious reactions necessitate prompt evaluation and supportive care

The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial

These metabolic disorders include changes in glucose and FA transport from the extracellular environment into the cytoplasm, anaerobic glycolysis in the cytoplasm, and mitochondrial oxidative phosphorylation (Zhi et al., 2016