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Mitochondrial ROS (mtROS) are detoxified by superoxide dismutase (SOD), which converts superoxide to hydrogen peroxide, followed by sequential clearance via catalase, glutathione peroxidase (GSH-Px), and the peroxiredoxin/thioredoxin (PRX/Trx) systems [85, 86]

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Counterpoint #6 Now heres where the authors really jumped the shark

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Firstly, the main strength is the long study follow-up (15 months), which allows for gathering information about potential changes in patients QoL in response to long-term ALC treatment, usually not be easily detectable in studies with shorter observation periods

Following antibody staining, erythrocytes were lysed using lysis buffer (BD FACS Lysing Solution, BD Biosciences, San Jose, USA) for 10 min on a shaker