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Here, we propose the misfolding of the mutant ATXN3 protein and the subsequent aggregation process, with eventual deposition of insoluble intracellular aggregates, to be the hub of the pathogenic process, and discuss how protein dyshomeostasis impacts key cellular pathways causing dysfunction and disease (Fig

Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: a randomized, double-blind, placebo-controlled trial

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All patients were examined for any other comorbidities