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Clonal evolution in actue leukemia

Not for human therapeutic use.

Jill James, Ph.D

As defined by Arthur Riggs and colleagues, it is "the study of mitotically and/or meiotically heritable changes in gene function that cannot be explained by changes in DNA sequence." [21] The term has also been used, however, to describe processes which have not been demonstrated to be heritable, such as some forms of histone modification

[51] NAC appears to be able to help restore CD4 cell function: in a study of 11 asymptomatic HIV-infected individuals with CD4+ counts of over 300/mL, N-acetylcysteine (at 5, 10 and 20 mM) restored normal CD4+ proliferative responses in 8 of 11 patient blood samples

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