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Key mechanisms include activation of the fibroblast growth factor receptor (FGFR) axis to drive tissue repair, modulation of the nitric oxide system governing vascular tone and inflammation, and interaction with AKT/mTOR and MAPK/ERK pathways involved in cell survival and proliferation

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In addition, under the context of studying central trained immunity as a basis for inflammatory comorbidities, experimental periodontitis-induced central trained immunity could be transferred to healthy mice via bone marrow transplantation, leading to more severe arthritis in a collagen antibody, induced arthritis model (82)

doi: 10.1007/978-3-8274-2440-2_7 144 BreitbartWRosenfeldBTobiasKPessinHKuGYYuanJet al

Healing takes several months as new tissue forms

Here, we synthesized a potent and selective TGR5 agonist OM8 with high distribution in intestinal tract and investigated its effect on IEC apoptosis and UC treatment