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Packham S, Warsito D, Lin Y, Vasilcanu D, Strmberg T, Jernberg-Wiklund H, et al

Selective activation of Ca2+-dependent PKCs by thymeleatoxin induces cholestasis and retrieval of Bsep from the canalicular membrane in the isolated perfused rat liver.144 Interestingly, the canalicular ATP-binding cassette transporter, multidrug resistance protein 1 (Mdr1), the closest homologue of Bsep, is phosphorylated by PKC at 3 serine residues at the C-terminal, linker region, which binds to the actin-associated protein, HAX-1.145 Whether this phosphorylation occurs also for Bsep remains to be ascertained

S., Khammanivong, A., Ross, K

If your daily injection volume falls below ~10 units, consider using a smaller (50-unit) syringe for better precision

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The positive charges of proteins typically attribute to ionized cysteine, aspartate, lysines, and histidines
