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OCT embedded brains were cut into 10 m sections, the sections were rinsed three times with PBS, blocked for 1 h in 8% bovine serum albumin (BSA) dissolved in 0.01 M phosphate buffer (PB) containing 0.5% Triton-X100

Angelman Syndrome: Ube3a Loss of expression of the ubiquitin-protein ligase E3a (UBE3A) is associated with most cases of Angelman syndrome, which is a rare syndrome of developmental delay, ID and ASD (Buiting et al., 2018), which points to a highly regulated role of UBE3A in the organism

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