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In a study of 10 healthy male volunteers, omeprazole, in doses of 20 mg40 mg per day, caused a significant decrease in the oral absorption of methylcobalamin, vitamin B12

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However, recent clinical evidence suggests the picture is more nuanced than previously understood

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Research indicates that low maternal B12 status is associated with a higher risk of adverse outcomes, including neural tube defects, preterm birth, low birth weight and potential impacts on cognitive development, although evidence of direct causation remains limited

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