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Alterations in methylation can lead to the elevation of homocysteine levels, called hyperhomocysteinemia which has been linked to a number of conditions related, but not limited to cardiovascular disease, neurological disorders and even cancer

The most common type of autophagy is macro-autophagy, in which a phagophore expands and engulfs the cytosolic components to become an autophagosome

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Levine DM, Parker TS, Donnelly TM, Walsh A, Rubin AL