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As previously discussed, bacterial products, collectively known as PAMPs and MAMPs, derived from the gut, reach the liver via portal circulation and systemic circulation through the mesenteric lymph nodes, and may induce an inflammatory response by activating Toll-like receptors (TLRs)

Ronneau, S., Michaux, C

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Piezo1 is expressed on the neuronal cell membrane in the vertebrate CNS and regulates important developmental processes, such as axon guidance