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doi: 10.1038/nature21349 39 ChenB.SunL.ZengG.ShenZ.WangK.YinL.et al

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Its reported effects on modulating inflammatory pathways make it a candidate for managing arthritis, joint pain, and other inflammatory disorders

171 Although research into brain stimulation is in its early stages, case reports of successful treatment using stimulation to the brain cortex or deeper brain structures indicate the potential for this method to be helpful in patients with severe tinnitus that has not responded to other therapies

LRRK2 is a widely expressed, large, single-polypeptide protein with multiple domains including ankyrin, leucine-rich repeat, WD40 repeats, and the catalytic core, Ras-of-complex proteins (ROC)-GTPase domain with serine/threonine kinase activities [127]

Efficacy and safety of upadacitinib for 16-week extended induction and 52-week maintenance therapy in patients with moderately to severely active ulcerative colitis