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Several metabolic disturbances have been reported in aged experimental animals, including glucose intolerance, insulin resistance, impaired oxidative phosphorylation, reduced mitochondrial biosynthesis, and decreased fatty acid oxidation [154]

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Production of XBP1s mRNA is a result of IRE1 catalyzed removal of a 26-nucleotide intron from XBP1 mRNA and ligation of the remaining fragments by the tRNA ligase RtcB (Yoshida et al

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[DOI] [PubMed] [Google Scholar] 46.Xie X., Corradetti G., Song A., Pardeshi A., Sultan W., Lee J.Y., Yu F., Zhang L., Chen S., Chopra V., et al

doi: 10.1146/annurev.arplant.043008.091948