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This response acts to delay pathology and suppresses ferroptosis, by promoting antioxidative factors, such as glutathione 159

The glutathione-deficient, cadmium-sensitive mutant, cad2-1, of Arabidopsis thaliana is deficient in gamma-glutamylcysteine synthetase

This suppression results in decreased T3 production and a compensatory rise in rT3, an inactive thyroid hormone metabolite that competes with T3 for receptor binding