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Besides, the tyrosine kinase inhibitor sorafenib, which is approved for the treatment of liver renal and thyroid carcinoma and also showed efficacy in AML patients with FLT3-ITD (181, 182), also inhibits the system Xc - (183)

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Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

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[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Schwartz S.S., Epstein S., Corkey B.E., Grant S.F.A., Gavin Iii J.R., Aguilar R.B., Herman M.E
doi: 10.1038/s41573-018-0008-x 50 CunhaL
