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Advanced glycation end product (AGE) production by fructose and its metabolites (3-deoxyglucosone, glyceraldehyde-3-phosphate, and methylglyoxal) is also augmented [34,35]

However, excessive supplementation may lead to potential and substantial side effects [18]

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for example, 5-fluorouracil suppresses p300/CBP, decreases histone acetylation, and induces autophagy in colorectal cancer

In influenza-infected mice, moderate-intensity training reduced pulmonary IFN- gene expression and shifted a Th1 inflammatory to a Th2 anti-inflammatory response, increasing survival rates (67)