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Nucleophilic co-substrate to glutathione transferases and electron donor to glutathione peroxidases

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These mutants were also more susceptible than WT to another ITC, sulforaphane

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Chronic activation of inflammasome signaling in microglia and astrocytes, characterized by the upregulation of NLRP3 and NF-B, has been linked to the establishment of a neuroinflammatory environment, leading to synaptic loss and exacerbating tau pathology