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La sintesi endogena avviene a partire dal substrato TML (6-N-trimetillisina), che a sua volta deriva dalla metilazione dell'amminoacido lisina

In the attempts to study CAD and the causative agents for the disease, a metabolite circulating in the plasma termed trimethylamine-N-oxide (TMAO) has been found out to be an independent risk factor that increases CAD risk

This makes it a potential treatment option for those suffering from mood disorders

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