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But in a review published in the journal Food Research International , researchers noted that the weight loss effects of CLA may be small, and that more studies are needed on people in the general population

ROS may accumulate due to: Environmental toxins Inflammation Radiation exposure Aging Source: International Journal of Molecular Science Environmental Toxins / Drugs Certain toxins or drugs may damage mitochondria or inhibit respiratory chain enzymes, such as: Pesticides (e.g., rotenone, paraquat) Alcohol Antibiotics (e.g., chloramphenicol) Antiretrovirals (e.g., nucleoside reverse transcriptase inhibitors) Source: Current Environmental Health Reports Nutrient Deficiencies Mitochondrial function depends on cofactors and nutrients such as: Coenzyme Q10 (ubiquinone) B vitamins (especially B1, B2, B3, B5) L-carnitine Magnesium Alpha-lipoic acid Deficiencies may impair ATP production or increase oxidative burden

10.1038/s41598-019-49870-y 54 GhanekarS

Targeting IDH1 as a prosenescent therapy in high-grade serous ovarian cancer

PMID: 31701550.

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