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Histone-lysine N-methyltransferase 2D (KMT2D, MLL4) is an important epigenetic regulator ( Mll4 epidermal-specific knockout mice and found that Mll4 deficiency in the epidermis impacts epidermal differentiation and disrupts skin homeostasis in mice

Glutathione is a natural antioxidant produced in the body, working quietly behind the scenes to fight free radicals (the stuff that ages skin and makes it look tired)

Respiratory burst requires a 10 to 20 fold increase in oxygen consumption through NADPH oxidase (NOX2 in humans) activity

Science 347:12531256 Seki S, Kitada T, Yamada T, Sakaguchi H, Nakatani K, Wakasa K (2002) In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases

Non-diabetic subjects were volunteers from academic institutions in Pune

The study found that the PKC pathway was not directly responsible for the activation of ARE by DATS