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Metabolic rate and energy expenditure: While AOD9604 mainly works through direct effects on fat cells, some research suggests it may also modestly increase metabolic rate and energy expenditure

What the science suggests (preclinical): Supports a longer growth phase (anagen) by promoting dermal papilla cell activity and survival

During the micro-needling process, fine needles puncture the skin minimally to produce small, controlled skin damage that stimulates renewed production of elastin and collagen

AOD9604 is a synthetic peptide analog derived from the C-terminal region of human growth hormone

Emerging work looks at its potential in muscle biology, where NNMT inhibition may support muscle stem cell function and regeneration

"Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice." Biochemical Pharmacology