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The truncated form of keratin promotes cell metastasis by affecting the structure of desmosomes and cell-cell adhesion [5]

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TYR, a key enzyme in the melanin biosynthesis pathway, catalyzes the conversion of tyrosine to dihydroxyphenylalanine (DOPA) and subsequently to DOPA quinone, which are critical steps in melanin production

The latter is an imbalance between the generation and elimination of ROS in favor of the former with various consequences for cell physiology (Lushchak, 2014b)

Three major MAPKs are c-JUN N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK)