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When it was recognized that pellagra, a condition marked by diarrhea, dermatitis, dementia, and mortality, could be treated with foods containing NAD+ precursors, particularly vitamin B3, the clinical significance of maintaining NAD+ levels was established in the early 1900s (9). Notably, the skin does not flush with NAD+ injection, in contrast to vitamin B3 (niacin) intake, which also causes this negative effect (10). Low NAD+ levels have recently been associated with a variety of age-related ailments and diseases linked to increased oxidative/free radical damage, including diabetes, heart disease, vascular dysfunction, ischemic brain injury, Alzheimers disease, and vision loss (8, 11-17)

Always provide your healthcare provider with a complete list of your medications and supplements

In a very practical sense, B12 and other water-soluble vitamins are the safest and easiest nutrients to supplement because your body takes what it needs and gets rid of what it doesnt

If your cat starts eating after using one (or a combination) of these tricks, then you can possibly chalk it up to an upset stomach that will pass, a change in the weather, or something non-threatening

For individuals with conditions like pernicious anaemia, an autoimmune disorder that attacks the protein needed to absorb B12, oral supplements are often completely ineffective