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Beyond the gut, a growing body of preclinical evidence suggests it plays a critical role in orchestrating the repair of the musculoskeletal system, specifically by accelerating the healing of bone fractures, ruptured tendons, torn ligaments, and damaged muscle fibers

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Talanta 144 , 258262 (2015)

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However, as discussed in the next section, key historical events affecting APAP use in the pediatric population have been documented that can be useful in estimating APAP use through time