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In the periplasmic leaflet, enzymes can modify the phosphate moieties in the 1- and 4-positions of the disaccharide backbone by hydrolysis or by the addition of cationic sugars or phosphoethanolamine to prevent binding to host defence molecules so influencing the virulence of some pathogens and their resistance to antibiotics

doi: 10.1007/s00216-015-8728-9

doi: 10.1021/acs.analchem.9b01241

Additionally, Neuroblastoma will not test positive for certain markers (cytokeratin, HMB-45) and lacks certain neuroendocrine markers seen in MNTI

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