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KAT8-catalyzed lactylation promotes eEF1A2-mediated protein synthesis and colorectal carcinogenesis

Many molecular pathways that promote the development of NAFLD, such as early IR, gut microbiota and metabolites, are involved in hepatocyte lipotoxic stress and injury, and further contribute to hepatocyte senescence and death, stellate cell activation and fibrosis (Wang et al., 2023)

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[7] [8] Weight regain typically follows discontinuation, and concerns persist regarding disproportionate lean mass loss during rapid reduction, potentially exacerbating sarcopenia in vulnerable populations, as empirical data highlight the need for combined lifestyle interventions to preserve muscle

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