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In addition, up-regulation of NOX2 has been detected in the SN of PD patients and a mouse model of PD, and that over-activated NOX2 is a major source of oxidative stress under inflammatory conditions [119]

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Yeast cells were washed with PBE and incubated with a 1:20 dilution of Streptavidin MicroBeads (Miltenyi Biotec, 130-048-101) for 30 min

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665 Although this approach might help in preventing large insoluble aggregates, it paradoxically supports a dynamic pool of toxic oligomers that evade normal clearance mechanisms