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However, in many cases peripheral symptoms, such as muscle fatigue, either prevail or are an important part of the clinical presentation

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This drop is linked to greater susceptibility to age-related conditions like cognitive decline[4] and metabolic dysfunction[5]

doi: 10.1111/eci.13412 104 EdalatifardMAkhtariMSalehiMNaderiZJamshidiAMostafaeiSet al

The answer is more nuanced than you might think
