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Unlike vitamins, LC is synthesized endogenously in humans but becomes conditionally essential under certain physiological demands, such as prolonged or high-intensity exercise (Alesci et al

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The search strategy included combinations of the following Medical Subject Headings (MeSH) terms and keywords: carnitine, L-carnitine, hemodialysis, dialysis, end-stage renal disease, ESRD, and supplementation

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The body also excretes excess plasma carnitine in urine, which is one reason more is not automatically better

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