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Circulation 145 , e153e639 (2022)

Translation of these therapies to the clinic requires extensive evaluation of safety and efficacy in humans which is currently lacking for this new class of compounds

Individual results vary, and IV therapy is not intended to diagnose, treat, cure, or prevent disease

Results FoB and MZB exhibit distinct glutathione-based redox dependencies To dissect the redox state of MZB and FoB in relation to the main antioxidant GSH, we studied the expression of Gclc , which is necessary for GSH synthesis 24 , in isolated MZB and FoB from spleens of C57BL/6J (B6 or wild-type) mice

Notably, the administration of Trolox effectively mitigated BLM-induced lipid peroxidation and attenuated the progression of PF [59]

Specifically, nanozymes can induce immunogenic cell death through various mechanisms, such as alloy nanoparticles like Cu-Ag NPs [136] or FeCu-DA [137], as well as nanozyme platforms [138]