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In parallel, cultured hepatocyte models (alpha mouse liver 12 [AML12] cells) with RAP1A knockdown or overexpression were used to assess cellular lipid accumulation, fatty acid oxidation, and mechanistic pathways

Abbott NJ, Patabendige AAK, Dolman DEM, Yusof SR, Begley DJ

Influencing Factors and Limitations The limitation of transdermal absorption rate L-carnitine features a relatively large molecular weight, which creates obvious barriers to skin penetration and makes it challenging to reach therapeutically effective concentrations when applied topically on its own

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