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In contrast, in the IMR-5/75 MNA cell line, (M+D)/2 reduced MYCN by half, while (M+D+V)/3 led to an even greater decrease ( Supplementary Figure S7B )

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Other clinically relevant species, such as Escherichia coli , Salmonella enterica , Neisseria gonorrhoeae , and Mycobacterium tuberculosis , also pose serious therapeutic challenges and contribute significantly to the global AMR burden [6, 7]