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doi: 10.1016/j.mad.2016.05.005

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doi:10.1074/jbc.R800046200 Burczynski ME, Sridhar GR, Palackal NT, Penning TM (2001) The reactive oxygen speciesand Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha, beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene

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Folate supplementation counteracts these effects by inhibiting NF-B activation, which dramatically lowers the levels of inflammatory cytokines such as IL-6 and TNF-, thereby reducing liver inflammation (Sid et al., 2018)

Additionally, careful consideration of patient eligibility, dose selection, and monitoring of treatment outcomes are essential to minimize risks and maximize benefits