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These mutants showed a low basal activity, but their activity could not be stimulated by SAM-like wild-type (Fig

Cagrilintide is an amylin receptor agonist that works through yet another pathway

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The final substrate concentration in 100 L total reaction volume was 5 M with 0.25% (v/v) dimethyl sulfoxide (DMSO)

Paradigm changes for GI malignancies treatment
