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5 Jiangsu Provincial Key Laboratory of Critical Care Medicine, Nanjing 210009, Peoples Republic of China Correspondence: Ruihua Shi Department of Gastroenterology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, Peoples Republic of China Tel +86 25 83262833 Fax +86 25 83262830 Email [email protected] Guoqiu Wu Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, Peoples Republic of China Tel +86-25 83272150 Email [email protected] Aim: Although Clopidogrel is safe in healthy volunteers, it can induce recurrence of gastric ulcers in high-risk patients

This can be ascribed to its modulatory effects on the NO-system [96,97,98,99,100] and prostaglandins-system [106,107], as mentioned above

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