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[DOI] [PubMed] [Google Scholar] 115.Bernardes de Jesus B., Vera E., Schneeberger K., Tejera A.M., Ayuso E., Bosch F., Blasco M.A

This study identified significant dose-response relationships for Cotadutide, Danuglipron, JNJ-64565111, Retatrutide, Orforglipron, and injectable Semaglutide (Equations Equation 1, Equation 2, Equation 3, Equation 4, Equation 5, Equation 6), with effective doses (doses achieving 50 % of the Emax value) of 0.219 mg, 80 mg, 6.73 mg, 4 mg, 14.6 mg, and 0.384 mg, respectively

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Previous studies that explored the effects of larger peptide GLP-1s such as semaglutide in the brain have found that they suppress hunger-driven eating by engaging networks in the hypothalamus and hindbrain

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