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Thus, it is possible that activation of GR in the heart is beneficial while MR activation is deleterious

However, evidence from meta-analyses indicated that nebivolol can significantly reduce the incidence and progression risk of ED [172]

doi: 10.3390/antiox10111702 122 ShihA

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Int J Mol Sci 20(18):4446 Bharti P, Mahajan M, Vishwakarma AK, Bhardwaj J, Yadav SK (2015) AtROS1 overexpression provides evidence for epigenetic regulation of genes encoding enzymes of flavonoid biosynthesis and antioxidant pathways during salt stress in transgenic tobacco

Furthermore, as Al toxicity induce water stress, these osmolyte function as osmoprotectants by reducing intracellular water potential, regulating turgor dynamics and stabilizing proteins and membrane integrity, thereby promoting Al tolerance (Ejaz et al., 2020)