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Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury

Treatment reduced tumor burden in the lungs, reduced the number of individual metastases, and improved overall survival

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Moreover, pharmacological inhibition of ACMSD by TES-991 and TES-102524 boosts de novo NAD + synthesis and SIRT1 activity, ultimately enhancing mitochondrial function in the liver, kidneys and brain of mice 216

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