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Description
the goal of this study was to develop an AnglV-derived molecule that retained the pro-cognitive/anti-dementia activity of AnglV and Nle'-AnglV but possessed improved pharmacokinetic properties, thus allowing it to penetrate the BBB in sufficient quantities to reach therapeutic levels in the brain
The NRF2 transcription factor orchestrates expression of GPX4, SLC7A11, and a suite of antioxidant enzymes

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doi: 10.1016/j.phrs.2015.07.021

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