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EGFR TKIs are expressed in keratinocytes, hair follicles, and sebaceous glands, so their inhibition results in disruption of the skin barrier, abnormal keratinization, and follicular inflammation mediated by IL-8, which generates acneiform rash and paronychia [15, 16]

Pasture-finishing of bison improves animal metabolic health and potential health-promoting compounds in meat

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It would also be valuable to examine more targeted assessments, such as CT calcium scores or coronary catheterizations, given that disrupted calcium and cholesterol dysregulation are known effects of elevated TMAO