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Small real-world series also suggest that reduced-frequency dosing can hold a plateau

The majority of the studies (see above in red) are preclinical studies in rodents, the vast majority of which have been done by a single research group in Croatia, which has been rinsing and repeating the same approach for decades

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Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat

The area under the plasma concentrationtime curve (AUC) was determined using the linear trapezoidal method with extrapolation to infinity

Numbness is risky because you are no longer able to rely on your sense of pain to tell you when something is wrong