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Orecchioni M, Ghosheh Y, Pramod AB, Ley K

Modulation of TRPV4 protects against degeneration induced by sustained loading and promotes matrix synthesis in the intervertebral disc

Here is a skim over of the current research on T4: Animal and in vitro research In animal models of stroke, traumatic brain injury, and multiple sclerosis, T4 has demonstrated neuroprotective and regenerative properties like supporting axonal growth, remyelination, and angiogenesis, and upregulating expression of tight junction proteins that contribute to blood-brain barrier integrity

McClure and Massari 2014

(77) found vascular pathways connecting the brain and cranial bone marrow, which functioned as a route for bone marrow cell migration

This allows for elevation of the depressed area of scarring