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Severe hypersensitivity reactions, including anaphylaxis, generalized urticaria, and hypotension, tachycardia, and bronchospasm, have been reported following local instillation or injection of methylene blue

In further experiments, the antidiabetic effects of NaBPC157 were further investigated with particular focus on their possible activity when applied intragastrically

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It can also interfere with levodopa therapy if levodopa is taken without carbidopa, as vitamin B can diminish levodopas therapeutic effect