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Research from the International Journal of Peptide Research found that freeze-thaw cycles reduced GHK-Cu bioactivity by 812% per cycle in fibroblast proliferation assays

[DOI] [PubMed] [Google Scholar] Gao Y, Yan CH, Yu XD, Wu SH

Cultured Purkinje neurons displayed both increased and reduced activity in response to IL-6, with cultures exposed to 10 ng/mL IL-6 showing reduced activity, while cultures exposed to 1 ng/mL showing increased activity (Nelson et al., 1999)

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The gene functions in the MEdarkslateblue module are concentrated in the leukotriene D4 biosynthetic process, glutathione catabolic process, acute inflammatory response, etc., and the corresponding enriched pathways are Glutathione metabolism and Bacterial invasion of epithelial cells