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in contrast, we did not observe demyelination in anterior regions (Supplementary Fig
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A 2026 International Journal of Molecular Sciences review confirmed plausible mechanisms: angiogenesis support, collagen synthesis, nitric oxide modulation all observed in animal models, not controlled human studies
It is also possible that in active acromegaly, chronic exposure to elevated IGF-I levels resets IGF-IR responsiveness via the induction of IGF-IR resistance (70), as it has been demonstrated that prolonged stimulation with IGF-I induces functional IGF-IR resistance in vitro through the negative feedback loop (72)