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Unlike apoptosis, which involves caspase activation and nuclear fragmentation, ferroptosis is initiated by iron accumulation and lipid peroxidation, resulting in membrane rupture without caspase involvement ( This review aims to comprehensively analyze recent advances in understanding ferroptosis mechanisms in CHD and evaluate emerging clinical intervention strategies

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The resultant active species are strong electrophiles and key to inhibiting tumor growth, but are themselves also prone to decomposition by hydrolytic reactions with water or by direct inactivating interactions with the abundance of nucleophilic targets in the cell

This aligns with previous studies indicating that aging is associated with decreased levels of BDNF (Lommatzsch et al